Using Databases to Interpret Cytogenomic Arrays


Date of Release:  January 1, 2012
Date of Renewal: January 1, 2015
Expiration Date:   January 1, 2018
Estimate Time of Completion: 6 hours



In this course, you will be introduced to web-based resources that will enable you to interpret patient microarray results.


Each lesson includes a downloadable PDF that you can refer to when watching the case videos or exploring the databases.  This course is based on half-day ACMG workshops developed by Dr. Darrel Waggoner and Dr. Christa Lese Martin

Technologies that allow for the evaluation of the entire human genome have become increasingly inexpensive and show great promise in clinical application.  Among the first of these technologies to move into the practitioner's clinic are the cytogenomic or chromosomal arrays that detect changes in copy number of genetic material throughout the human genome.  Rare and new variations have been a part of cytogenetic analysis since its inception in the 1970s.  New technologies now allow the identification of structural changes in human chromosomes at levels of resolution not previously possible and with these, another level of rare and previously undetected variation is being detected.  And now, after several years of development and thousands of hours of work, ACMG has unveiled the highly anticipated, new web-based educational CME programs to help genetics and health experts to interpret these copy number variations, Using Databases to Interpret Cytogenomic Arrays.


At the conclusion of this enduring activity, participants should be able to:

  • Interpret rarely encountered copy number variations
  • Interpret the copy number variations provided in laboratory results
  • Recognize the phenotypic variations associated with different copy number variations


Christa Lese Martin PhD, FACMG
Director and Senior Investigator
Geisinger Health System 
Autism and Developmental Medicine Institute
Lewisburg, PA

Darrel Waggoner MD, FACMG
Human Genetics
Department of Pediatrics
University of Chicago
Chicago, IL

ACMG follows the ACCME policy on Content Validation for CME activities, which requires:

  • All the recommendations involving clinical medicine in a CME activity must be based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients.
  • All scientific research referred to, reported or used in CME in support or justification of a patient care recommendation must conform to the generally accepted standards of experimental design, data collection and analysis.

The registration fee is $500 for non-members and $50 for ACMG members and free for medical genetics trainees.  Registration must be completed in its entirety in order to proceed.  Please allow one full business day for processing.  Payment (in US funds) for online registration can be made by VISA, MasterCard or American Express.  Registrations received without payment will not be processed.


There is an additional $25 fee for the CME/CEU/P.A.C.E® credit. If you would like to register continuing education credits, please check the appropriate box at the bottom of the registration form. Once your registration is processed, you will receive an email containing the link to access the Self Reporting Form. You must complete the entire Self Reporting form with a score of 80% or greater to receive your certificate.*


*Please check the CME & CEU page for more information.


Access your CME Self-Reporting Form here. 
(Only those who have registered for the program and CME will be able to access the Self-Reporting Form.)

The files are .mov and run using the Apple QuickTime player.


Disclaimer: This ACMG tutorial on genomic databases, "Using Databases to Interpret Cytogenomic Arrays" is designed primarily as an educational tool for medical and clinical geneticists interested in the diagnosis, interpretation, management, treatment and prevention of genetic conditions who wish to increase their understanding of the genetic basis of common, chronic health problems affecting both children and adults. The ACMG does not endorse or recommend the use of this educational program to make patient diagnoses, particularly by individuals not trained in medical genetics.


Adherence to the information provided in this program does not necessarily ensure a successful diagnostic outcome. The program should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed to obtaining the same results. In determining the propriety of any specific procedure or test, a healthcare provider should apply his or her own professional judgment to the specific clinical circumstances presented by the individual patient or specimen.


The site contains links to third party websites. These links are provided solely as a convenience to users and not as a guarantee, warrantee, or recommendation by ACMG of the content on such third-party websites or as an indication of any affiliation, sponsorship or endorsement of such third party websites. ACMG is not responsible for the content of linked third-party sites and does not make any representations regarding the privacy practices of, or the content or accuracy of materials on, such third-party websites. If you decide to access linked third-party websites, you do so at your own risk. Your use of third-party websites is subject to the terms of use for such sites.




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